On a binder but can’t reach your phosphorus goal?
There’s a different approach
Block
Phosphorus
with XPHOZAH®(TENAPANOR)
As add-on therapy for adult patients on dialysis in whom a phosphate binder does not work well or cannot be tolerated
- XPHOZAH is not a binder, it’s a blocker
- XPHOZAH is dosed as one pill, twice a day
- XPHOZAH can help reduce serum phosphorus in adults
- XPHOZAH blocks phosphorus when taken just before you eat your first and last food of the day
High phosphorus
Know Your Numbers:
Understanding High Phosphorus
Phosphorus is an essential mineral found in foods like dairy and meat. Your body absorbs it when you eat—but when your kidneys aren’t working well, extra phosphorus can build up in your blood. This condition is called hyperphosphatemia (high phosphorus).
Too much phosphorus can harm your body over time and can lead to serious health issues, including bone weakening and heart problems.
That’s why it’s important to know your target phosphorus goal. Most doctors aim for 5.5 mg/dL or less, with the latest guidelines recommending a normal range of 2.5–4.5 mg/dL.
We understand how hard it can be to keep your phosphorus levels in range.
Nearly 70% of people with chronic kidney disease (CKD) on dialysis who are treated with a phosphate binder still struggle to get to goal and stay there.* If that’s been your experience, you’re not alone—and you’re not out of options.
This information comes from patient charts reviewed between 2019 and 2023. The charts looked at about 1,000 patients on dialysis each year who were also taking phosphate binders. The target phosphorus level was 5.5 mg/dL or lower.
*At least one phosphorus level was above 5.5 mg/dL during the 6-month review.
XPHOZAH is a prescription medication that may help you lower your phosphorus levels.
Managing phosphorus can be hard. See how XPHOZAH takes a different approach.
HOW XPHOZAH WORKS
XPHOZAH is a blocker and works
differently than phosphate binders
Binders bind phosphorus
Phosphate binders are like a sponge. They soak up some of the phosphorus in your gut, keeping it from entering your bloodstream.
But a sponge only works if it’s there when and where the spill happens. Imagine spilling a drink in the living room but your sponge is in the kitchen: it can’t do its job.
Binders work the same way. They must be in your gut when phosphorus is present.
That’s why phosphate binders need to be taken with every meal.
XPHOZAH
blocks phosphorus
XPHOZAH is not a binder,
it’s a blocker
XPHOZAH works like a roadblock, blocking some of the phosphorus from getting into your bloodstream.
Just like a roadblock stops traffic, XPHOZAH blocks phosphorus with one pill twice a day.
That’s why XPHOZAH is taken right before the first and last time you eat each day.
Ask your doctor if adding XPHOZAH to your treatment plan could help lower your phosphorus.
DOSING
How to take XPHOZAH
One pill, twice a day
TAKE 1 PILL right before you eat your first food of the day
TAKE 1 PILL right before you eat your last food of the day
- XPHOZAH is dosed as one 30 mg pill twice a day
- This is both your starting and max dose. Do not take more than the dose prescribed by your doctor. If you miss a dose, skip that dose but take your next dose at the regular time
- Stop the use of laxatives or stool softeners
- Do not take right before a hemodialysis session, as you may experience diarrhea after taking XPHOZAH. Instead, take before your next meal after dialysis
- Don’t adjust your dose without speaking to your doctor
SIDE EFFECTS
You may experience diarrhea, looser stool, and/or more frequent bowel movements after taking XPHOZAH
These changes are expected and reflect how XPHOZAH works in your body. XPHOZAH works by blocking phosphorus from being absorbed into the blood from the gut, which increases the amount of sodium and water in your stool, making it softer and causing more frequent bowel movements.
- Diarrhea is the most common side effect and is usually mild to moderate. 5% of patients reported having severe diarrhea
- If you experience diarrhea, it may happen soon after starting XPHOZAH, but can occur at any time during the treatment. It usually goes away within 2 weeks, or your doctor may lower your dose
- Call your doctor if you develop severe diarrhea
- During the clinical trials of XPHOZAH, participants were allowed to use anti-diarrheal medications like loperamide to manage diarrhea. Ask your doctor about the use of anti-diarrheal medications.
Access & Support
How to get XPHOZAH
- Your doctor will send your XPHOZAH prescription to a specialty pharmacy—the pharmacy will reach out to you via text or phone
- Keep an eye out for a text or call. You’ll need to respond so that you can get your prescription
- The specialty pharmacy will work with you to arrange the delivery of XPHOZAH to your home
Ardelyx is committed to helping patients access the medications they’ve been prescribed
Pay as little as $0* for XPHOZAH
$0
Patients with commercial insurance pay as little as $0 per 30-day prescription fill of XPHOZAH.
The discount will be automatically applied for eligible patients.
*Please see terms and conditions.
My Phosphorus Progress Chart
Use this tracker to help monitor your phosphorus levels and support conversations with your doctor about your treatment goals.
Download chart
Access to XPHOZAH: A Quick Guide
This quick guide outlines how your doctor can prescribe XPHOZAH despite the Medicare Part D changes.
Download and print to bring to your next appointment.
We’re here to help
Scan to download the ArdelyxAssist contact card. If you have questions or need support with XPHOZAH access or affordability, please reach out 1-877-527-3927 Option 3.
If your phosphorus is high,
take a different approach
Ask your healthcare provider about XPHOZAH and start blocking to help lower your phosphorus.
INDICATION
XPHOZAH (tenapanor) 30 mg BID is a prescription medicine used to reduce serum phosphorus in adults with chronic kidney disease (CKD) on dialysis, as add-on therapy when phosphate binders do not work well, or when phosphate binders cannot be tolerated.
IMPORTANT SAFETY INFORMATION
The most important information about XPHOZAH is:
- XPHOZAH may result in softer and/or more frequent bowel movements.
- Do not give XPHOZAH to children who are less than 6 years of age
Do not use XPHOZAH in:
- Children who are less than 6 years of age
- Patients who have a suspected bowel blockage
Before taking XPHOZAH, tell your healthcare provider about all of your medical conditions, including if you:
- are pregnant or plan to become pregnant
- are breastfeeding or plan to breastfeed
Do not use XPHOZAH with stool softeners or laxatives. Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
XPHOZAH can cause serious side effects, including:
Diarrhea is the most common side effect of XPHOZAH, and it can sometimes be severe. Call your doctor if you develop severe diarrhea.
These are not all the possible side effects of XPHOZAH. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects to www.fda.gov/medwatch.
For additional safety information, please see full Prescribing Information.
INDICATION
XPHOZAH (tenapanor) 30 mg BID is a prescription medicine used to reduce serum phosphorus in adults with chronic kidney disease (CKD) on dialysis as add-on therapy when phosphate binders do not work well, or when phosphate binders cannot be tolerated.
IMPORTANT SAFETY INFORMATION
The most important information about XPHOZAH is:
- XPHOZAH may result in softer and/or more frequent bowel movements.
- Do not give XPHOZAH to children who are less than 6 years of age
Do not use XPHOZAH in:
- Children who are less than 6 years of age
- Patients who have a suspected bowel blockage
Before taking XPHOZAH, tell your healthcare provider about all of your medical conditions, including if you:
- are pregnant or plan to become pregnant
- are breastfeeding or plan to breastfeed
Do not use XPHOZAH with stool softeners or laxatives. Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
XPHOZAH can cause serious side effects, including:
Diarrhea is the most common side effect of XPHOZAH, and it can sometimes be severe. Call your doctor if you develop severe diarrhea.
These are not all the possible side effects of XPHOZAH. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects to www.fda.gov/medwatch.
For additional safety information, please see full Prescribing Information.