XPHOZAH (tenapanor) 30 mg BID is a prescription medicine used to reduce serum phosphorus in adults with chronic kidney disease (CKD) on dialysis as add-on therapy when phosphate binders do not work well, or when phosphate binders cannot be tolerated.

The most important information about XPHOZAH is:

• XPHOZAH may result in softer and/or more frequent bowel movements.
• Do not give XPHOZAH to children who are less than 6 years of age

Do not use XPHOZAH in:

• Children who are less than 6 years of age
• Patients who have a suspected bowel blockage

Before taking XPHOZAH, tell your healthcare provider about all of your medical conditions, including if you:

• are pregnant or plan to become pregnant
• are breastfeeding or plan to breastfeed

Do not use XPHOZAH with stool softeners or laxatives. Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

XPHOZAH can cause serious side effects, including:
Diarrhea is the most common side effect of XPHOZAH, and it can sometimes be severe. Call your doctor if you develop severe diarrhea.

These are not all the possible side effects of XPHOZAH. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects to www.fda.gov/medwatch.

For additional safety information, please see full Prescribing Information.